Role of protein kinases in regulation of chromosome segregation
Project leader: Ľuboš Čipák
Project duration: 2014 - 2017
Meiosis is a specialized cell cycle that reduces the chromosome number by half to allow sexual reproduction. Complexity of chromosome segregation is pointing out the importance of the regulatory mechanisms that ensure the correct functions of all proteins involved in this process. The project is aimed to analyze in depth the role of protein kinases required for proper segregation of chromosomes during meiosis and to understand the underlying molecular mechanisms of its regulation. Specifically, we will use created knock-out and conditional analog-sensitive alleles of protein kinases to study their role in regulation of meiotic processes. We will elucidate role of protein kinases in meiotic recombination, mono-orientation of sister kinetochores and protection of centromeric cohesion. Obtained results could reveal much about the mechanism of gamete development and sexual reproduction with possible implications for diagnostics and treatment of infertility, certain cancers and genetic diseases.