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Laboratory of Molecular Genetics
Numerous chemical and physical agents that could be either endogenous or exogenous are constantly challenging DNA integrity. Since DNA is neither disposable nor recyclable, the consequences of unrepaired DNA damage are mutations, cell ageing or cell death. It is therefore not surprising that a variety of mechanisms evolved to cope with DNA damage and thus protect DNA integrity. The research interest of the Laboratory is focused on the mechanisms of DNA repair processes in prokaryotes, lower eukaryotes and higher eukaryotes with the following research topics:
  • Oxidative demethylation pathway
  • DNA double-strand break repair in eukaryotic cells
  • Validation of sensitive assay for prediction of radiosensitivity in breast cancer therapy
  • Cloning, expression and purification of human homologues XPB and XPD proteins from hyperthermophilic Archaeon, Pyrococcus abyssi
  • The role of the DNA repair helicases in nucleotide excision repair, base excision repair and transcription-coupled repair in mammalian cells

Head of laboratory: Chovanec Miroslav

Scientists
  • Chovanec Miroslav
  • Gurský Ján
  • Kleibl Karol
  • Mániková Dominika
  • Piršel Miroslav
Technicians
  • Hurbanová Lenka
  • Vlasáková Dana
PhD students
  • Loduhová Jana
  • Stanová Kristína
  • Šestáková Zuzana
Others
  • Polakovičová Erika
  • Vigašová Dana
Projects

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